Diabetes can reduce your immunity to fight diseases
Often seen that diabetic people are prone to more diseases. The uncontrolled diabetes can make it difficult to control infections as high blood sugar can release destructive molecules that interfere with the body’s natural infection-control mechanism, according to a research.
Author Janna Kiselar from Case Western Reserve University School of Medicine in Cleveland, Ohio, US says “Our in vitro findings alone could have a significant impact on development of more effective antimicrobial treatment strategies for patients with uncontrolled diabetes. The findings also emphasize the importance of lowering high blood sugar and keeping it under control”.
Dicarbonyls are the harmful molecules, breakdown products of glucose, interfere with infection-controlling antimicrobial peptides known as beta-defensins.
Senior author Wesley, who conducted the research in Case Western Reserve University School of Dental Medicine, noted that “If our findings hold up in future in vivo animal experiments and in human tissues, we will have solid evidence for how this dicarbonyl mechanism works in the setting of uncontrolled diabetes to weaken hBD-2 function, and that of other beta-defensins,”
The findings were published in the journal PLOS ONE.